Ces1c^tm1.1Loc
Targeted Allele Detail

Summary

• Symbol: Ces1c^tm1.1Loc
• Name: carboxylesterase 1C; targeted mutation 1.1, Oksana Lockridge
• MGI ID: MGI:4938302
• Gene: Ces1c Location: Chr8:93825643-93857911 bp, - strand Genetic Position: Chr8, 44.99 cM
• Alliance: Ces1c^tm1.1Loc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168821
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 5, and a neomycin resistance (neo) cassette followed by a single loxP site downstream of exon 5. Cre-mediated recombination removed exon 5 and the neo cassette. This deletion is predicted to abolish protein function. The absence of carboxylesterase activity in the plasma was confirmed by enzymatic assay. (J:168821)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ces1c Mutation: 38 strains or lines available

References

• Original: J:168821 Lockridge O, Direct Data Submission 2011/02/25. MGI Direct Data Submission. 2011
• All: 12 reference(s)