Klra5^tm1.1Cgbr
Targeted Allele Detail

Summary

• Symbol: Klra5^tm1.1Cgbr
• Name: killer cell lectin-like receptor, subfamily A, member 5; targeted mutation 1.1, Colin G Brooks
• MGI ID: MGI:4941892
• Synonyms: Ly49E^bgeo
• Gene: Klra5 Location: Chr6:129874715-129890188 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Klra5^tm1.1Cgbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169142
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2, exon 3, and exon 4 were replaced with a beta-geo cassette, stop codon, and FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. (J:169142)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Klra5 Mutation: 34 strains or lines available

References

• Original: J:169142 Aust JG, et al., Mice lacking Ly49E show normal NK cell development and provide evidence for probabilistic expression of Ly49E in NK cells and T cells. J Immunol. 2011 Feb 15;186(4):2013-23
• All: 1 reference(s)