Selenon^tm1.2Mred
Targeted Allele Detail

Summary

• Symbol: Selenon^tm1.2Mred
• Name: selenoprotein N; targeted mutation 1.2, Mathieu Rederstorff
• MGI ID: MGI:4946396
• Gene: Selenon Location: Chr4:134265203-134279477 bp, - strand Genetic Position: Chr4, 66.85 cM, cytoband D3
• Alliance: Selenon^tm1.2Mred page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168699
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neo cassette. Western blot analysis on skeletal muscle. heart, lung, liver, brain, and kidney extracts confirmed the absence of protein expression. (J:176499)

Disease models

Expression

In Mice Carrying this Mutation:	19 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Selenon Mutation: 26 strains or lines available

References

• Original: J:168699 Castets P, et al., Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency. Hum Mol Genet. 2011 Feb 15;20(4):694-704
• All: 8 reference(s)