Igh-8^tm2.1Aak
Targeted Allele Detail

Summary

• Symbol: Igh-8^tm2.1Aak
• Name: immunoglobulin heavy chain 8 (heavy chain of IgG3); targeted mutation 2.1, Ahmed Khamlichi
• MGI ID: MGI:4950363
• Synonyms: Sgamma3-pAp
• Gene: Igh-8 Location: Chr12:113329416-113330847 bp Genetic Position: Chr12, Syntenic
• Alliance: Igh-8^tm2.1Aak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171251
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A transcriptional terminator cassette containing two polyadenylation signals in the sense orientation and three in the antisense orientation was inserted together with a floxed neomycin selection cassette about 500 bp downstream of the Sgamma3 core repeats. The selection cassette was subsequently removed by cre mediated excison. (J:171251)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh-8 Mutation: 5 strains or lines available

References

• Original: J:171251 Haddad D, et al., Sense transcription through the S region is essential for immunoglobulin class switch recombination. EMBO J. 2011 Apr 20;30(8):1608-20
• All: 1 reference(s)