Tg(Pdx1-cre/Esr1*)#Dam
Transgene Detail

Summary

• Symbol: Tg(Pdx1-cre/Esr1*)#Dam
• Name: transgene insertion, Douglas A Melton
• MGI ID: MGI:5008261
• Synonyms: Pdx1-CreER
• Transgene: Tg(Pdx1-cre/Esr1*)#Dam Location: unknown
• Alliance: Tg(Pdx1-cre/Esr1*)#Dam page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pdx1-cre/Esr1*)#Dam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pdx1

• Mutation details: The sequence encoding a tamoxifen-inducible form of a cre recombinase/estrogen receptor fusion protein was adjoined to the Ipf1 promoter to drive mosaic expression of cre recombinase in endocrine, exocrine, and duct tissue of the pancreas. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:76095)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdx1 (species not specified) Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pdx1-cre/Esr1*)#Dam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:172243 Porat S, et al., Control of pancreatic beta cell regeneration by glucose metabolism. Cell Metab. 2011 Apr 6;13(4):440-9
• All: 63 reference(s)