Slc17a6^tm2(cre)Lowl
Targeted Allele Detail

Summary

• Symbol: Slc17a6^tm2(cre)Lowl
• Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; targeted mutation 2, Bradford B Lowell
• MGI ID: MGI:5141269
• Synonyms: Vglut2^Cre, Vglut2-ires-Cre
• Gene: Slc17a6 Location: Chr7:51271754-51320867 bp, + strand Genetic Position: Chr7, 32.78 cM, cytoband B4
• Alliance: Slc17a6^tm2(cre)Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174691
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Slc17a6^tm2(cre)Lowl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc17a6 (MGI:2156052)

• Mutation details: A targeting vector, constructed from a BAC clone containing the Slc17a6 (Vglut2) gene, was utilized to insert an internal ribosomal entry site followed by the cre recombinase sequence and an frt-flanked kanamycin/neomycin (kan/neo) resistance cassette into the Slc17a6 locus just downstream of the endogenous stop codon. Cre is expressed from the Slc17a6 gene promoter. (J:174691)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc17a6 (mouse) Summary of all recombinase alleles driven by Slc17a6. Comparative matrix view of recombinase activities Alliance mouse Slc17a6 gene page

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Slc17a6 Mutation: 60 strains or lines available

References

• Original: J:174691 Vong L, et al., Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons. Neuron. 2011 Jul 14;71(1):142-54
• All: 508 reference(s)