Ubr2^{tm1e(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Ubr2^{tm1e(KOMP)Mbp}
• Name: ubiquitin protein ligase E3 component n-recognin 2; targeted mutation 1e, Mouse Biology Program, UC Davis
• MGI ID: MGI:5293853
• Gene: Ubr2 Location: Chr17:47239221-47321482 bp, - strand Genetic Position: Chr17, 22.91 cM
• Alliance: Ubr2^{tm1e(KOMP)Mbp} page
• IMPC: Ubr2 gene page

Mutation origin

• Mutant Cell Lines: DEPD00576_2_A09, DEPD00576_2_A11, DEPD00576_2_C09, DEPD00576_2_C10, DEPD00576_2_C11, DEPD00576_2_D10, DEPD00576_2_E09, DEPD00576_2_E12, DEPD00576_2_F09, DEPD00576_2_F10, DEPD00576_2_F12, DEPD00576_2_G09, DEPD00576_2_G12, DEPD00576_2_H09, DEPD00576_2_H10
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 47302391 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Ubr2 Mutation: 86 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 2 reference(s)