Tg(Krt15-dnLef1)1Niem
Transgene Detail

Summary

• Symbol: Tg(Krt15-dnLef1)1Niem
• Name: transgene insertion 1, Catherin Niemann
• MGI ID: MGI:5296852
• Synonyms: K15deltaNLef1
• Transgene: Tg(Krt15-dnLef1)1Niem Location: unknown
• Alliance: Tg(Krt15-dnLef1)1Niem page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A myc-tagged dominant-negative Lef1 DNA fragment was inserted into a plasmid behind a 5 kb Krt15 promoter fragment. The construct was linearized for microinjection. Three low expressing founders were obtained and lines were established. A representative line 1 was entered. (J:175633)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:175633 Petersson M, et al., TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis. EMBO J. 2011;30(15):3004-18
• All: 3 reference(s)