Panx1^tm1.1Fama
Targeted Allele Detail

Summary

• Symbol: Panx1^tm1.1Fama
• Name: pannexin 1; targeted mutation 1.1, Fabio Mammano
• MGI ID: MGI:5297171
• Synonyms: Panx1^tm1Mony
• Gene: Panx1 Location: Chr9:14917081-14956774 bp, - strand Genetic Position: Chr9, 4.52 cM
• Alliance: Panx1^tm1.1Fama page

Panx1^tm1.1Fama/Panx1^tm1.1Fama Panx2^tm1.1Mony/Panx2^tm1.1Mony mice are protected in a stroke model

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178055
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: A lacZ gene and floxed neo cassette was inserted into exon 1. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by quantitative RT-PCR on hippocampus extracts. (J:177671, J:178055)

Generation of the Panx1^tm1.1Fama allele

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Panx1 Mutation: 38 strains or lines available

References

• Original: J:178055 Anselmi F, et al., ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18770-5
• All: 20 reference(s)