Clec9a^tm1.1Crs
Targeted Allele Detail

Summary

• Symbol: Clec9a^tm1.1Crs
• Name: C-type lectin domain family 9, member a; targeted mutation 1.1, Caetano Reis e Sousa
• MGI ID: MGI:5298406
• Synonyms: Clec9a^gfp
• Gene: Clec9a Location: Chr6:129385825-129401726 bp, + strand Genetic Position: Chr6, 63.3 cM
• Alliance: Clec9a^tm1.1Crs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178441
• Parent Cell Line: S6B6 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the C-type lectin domain family 9, member a (Clec9a) coding region with a farnesylated form of enhanced green fluorescent protein (EGFP), a polyadenylation signal, and a loxP-flanked neomycin (neo) resistance cassette. Cre-mediated recombination removed the neo cassette. (J:147472)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Clec9a Mutation: 29 strains or lines available

Notes

The expression of NK1.1 (Klrb1c) is linked to Clec9a deficiency in homozygous mice, indicating that the homologous recombination step targeted the chromosome of C57BL/6J origin.

References

• Original: J:178441 Reis e Sousa C, Direct Data Submission 2011/12/16. MGI Direct Data Submission. 2011
• All: 19 reference(s)