Tg(SIRPA)1Flv
Transgene Detail

Summary

• Symbol: Tg(SIRPA)1Flv
• Name: transgene insertion 1, Richard A Flavell
• MGI ID: MGI:5300383
• Synonyms: hSIRPa
• Transgene: Tg(SIRPA)1Flv Location: unknown
• Alliance: Tg(SIRPA)1Flv page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:175623
• Parent Cell Line: V17 (ES Cell)
• Strain of Origin: BALB/cAnNTac x 129S4/SvJae

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SIRPA)1Flv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SIRPA (140885)

  Sirpa

  (MGI:108563)

• Mutation details: The transgene contains a BAC encoding the entire 45 kb human SIRPA gene along with about 51 kb of 5' flanking DNA and 78 kb 3' flanking sequence. Line 1 was generated. (J:175623)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Previously targeted V17 ES cells carrying Rag2^tm1.1Flv and Il2rg^tm1.1Flv were used to generate the transgene.

References

• Original: J:175623 Strowig T, et al., Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13218-23
• All: 14 reference(s)