Hopx^{tm2.1(cre/ERT2)Joe}
Targeted Allele Detail

Summary

• Symbol: Hopx^{tm2.1(cre/ERT2)Joe}
• Name: HOP homeobox; targeted mutation 2.1, Jonathan A Epstein
• MGI ID: MGI:5300731
• Synonyms: Hopx^ERCre
• Gene: Hopx Location: Chr5:77234835-77262968 bp, - strand Genetic Position: Chr5, 41.45 cM
• Alliance: Hopx^{tm2.1(cre/ERT2)Joe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178296
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Hopx^{tm2.1(cre/ERT2)Joe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hopx (MGI:1916782)

• Mutation details: An IRES-cre/ERT-Frt-PGK-neo-Frt cassette was inserted into the 3' UTR of the Hopx locus by homologous recombination in ES cells. Subsequently, these animals were crossed to mice expressing the Tg(ACTFLPe)9205Dym recombinase allele to remove the PGK-neo cassette. (J:178296)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hopx (mouse) Summary of all recombinase alleles driven by Hopx. Comparative matrix view of recombinase activities Alliance mouse Hopx gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hopx Mutation: 11 strains or lines available

References

• Original: J:178296 Takeda N, et al., Interconversion between intestinal stem cell populations in distinct niches. Science. 2011 Dec 9;334(6061):1420-4
• All: 37 reference(s)