Tg(Rho-Sag*)240Seva
Transgene Detail

Summary

• Symbol: Tg(Rho-Sag*)240Seva
• Name: transgene insertion 240, Vsevolod Gurevich
• MGI ID: MGI:5301175
• Synonyms: 3A-240, Tg(Rho-Sag*)2Seva, Tg(Sag*3A240)2Seva
• Transgene: Tg(Rho-Sag*)240Seva Location: unknown
• Alliance: Tg(Rho-Sag*)240Seva page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rho-Sag*)240Seva expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sag (MGI:98227)

• Mutation details: The transgenic construct contains three amino acid substitutions (Leu374Ala, Val375Ala, and Phe376Ala) introduced into the mouse retinal S-antigen (arrestin; (GenBank M24086)) coding sequence under the direction of the mouse rod opsin promoter. Line 1 and 2 with moderate and high expression were generated from founders 3A50 and 3A240, respectively. (J:99855)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:99855 Nair KS, et al., Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005 May 19;46(4):555-67
• All: 6 reference(s)