Tnfsf11^tles
Chemically induced Allele Detail

Summary

• Symbol: Tnfsf11^tles
• Name: tumor necrosis factor (ligand) superfamily, member 11; toothless
• MGI ID: MGI:5307891
• Synonyms: RANKL^G278R
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^tles page

Mutation origin

• Strain of Origin: C57BL/6J x 129S6/SvEvTac

Mutation description

• Allele Type: Chemically induced (ENU) (Dominant negative)
• Mutation: Single point mutation
• Mutation details: ENU-mutagenesis induced a point mutation (G to A) that results in the amino acid substitution of glycine with arginine at position 278 (p.G278R) in the encoded protein. The predicted protein is a dominant negative form. (J:179743)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 32 strains or lines available

References

• Original: J:179743 Douni E, et al., A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet. 2012 Feb 15;21(4):784-98
• All: 3 reference(s)