Tg(Thy1-TARDBP*G298S)S97Pcw
Transgene Detail

Summary

• Symbol: Tg(Thy1-TARDBP*G298S)S97Pcw
• Name: transgene insertion S97, Philip C Wong
• MGI ID: MGI:5308398
• Transgene: Tg(Thy1-TARDBP*G298S)S97Pcw Location: unknown
• Alliance: Tg(Thy1-TARDBP*G298S)S97Pcw page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-TARDBP*G298S)S97Pcw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: This transgene contains the mouse Thy1 (thymus cell antigen 1, theta, promoter (Thy1.2)) promoter driving expression of the full-length human TAR DNA binding protein (TARDBP) cDNA sequence. A missense mutation associated with amyotrophic lateral sclerosis (ALS) was introduced at position 298 results in a glycine-to-serine substitution (G298S). Line S97 was established. (J:180948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:180948 Wong PC, Direct Data Submission 2012/03/02. MGI Direct Data Submission. 2012
• All: 4 reference(s)