Tg(Wap-HBx)1Gmn
Transgene Detail

Summary

• Symbol: Tg(Wap-HBx)1Gmn
• Name: transgene insertion 1, Marianne Bruggemann
• MGI ID: MGI:5312872
• Synonyms: WAP-HBX1
• Transgene: Tg(Wap-HBx)1Gmn Location: unknown
• Alliance: Tg(Wap-HBx)1Gmn page

Transgene origin

• Strain of Origin: NMRI

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene consists of a 1600 bp DNA fragment containing the promoter of the mouse whey acidic protein gene joined to nucleotides 1372-1822 of the hepatitis B virus (subtype group ayw) genome, encoding the HBV-x protein, followed by a DNA fragment encoding the FLAG epitope tag (DYKDDDDF). Expression of the transgene is detected by northern and western blot analysis and is demonstrated by RT-PCR analysis to correspond to that of the endogenous whey acidic protein gene during pregnancy, lactation and post-lactation involution of the mammary epithelial tissue. (J:83717)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two transgenic lines were generated and called by the authors WAP-HBX1 and WAP-HBX2. (J:83717)

References

• Original: J:83717 Klein A, et al., HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53. Oncogene. 2003 May 15;22(19):2910-9
• All: 1 reference(s)