Nr1d2^tm1.1Rev
Targeted Allele Detail

Summary

• Symbol: Nr1d2^tm1.1Rev
• Name: nuclear receptor subfamily 1, group D, member 2; targeted mutation 1.1, Ronald M Evans
• MGI ID: MGI:5426699
• Synonyms: Rev-erb-b^lox
• Gene: Nr1d2 Location: Chr14:4230569-4265642 bp, + strand Genetic Position: Chr14, 7.08 cM
• Alliance: Nr1d2^tm1.1Rev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183855
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:183855)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1d2 Mutation: 25 strains or lines available

References

• Original: J:183855 Cho H, et al., Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature. 2012 May 3;485(7396):123-7
• All: 17 reference(s)