Tyk2^tm3.1Biat
Targeted Allele Detail

Summary

• Symbol: Tyk2^tm3.1Biat
• Name: tyrosine kinase 2; targeted mutation 3.1, Biomodels Austria
• MGI ID: MGI:5438771
• Synonyms: Tyk2^K923E, Tyk2^{tm3(K923E)Biat}
• Gene: Tyk2 Location: Chr9:21015364-21042539 bp, - strand Genetic Position: Chr9, 7.71 cM, cytoband A3
• Alliance: Tyk2^tm3.1Biat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 20 was replaced with a modified one in which nucleotide substitutions (AAG GCC CTG to GAG GCC CTT) result in the amino acid substitution of glutamic acid for lysine at position 923 (K923E) and introduced a BspTI restriction enzyme site. A floxed neo cassette inserted downstream of exon 21 was removed by cre-mediated recombination. In vitro kinase activity confirmed the absence of activity. (J:187818)

Generation of the Tyk2^tm3.1Biat allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyk2 Mutation: 72 strains or lines available

References

• Original: J:187818 Prchal-Murphy M, et al., TYK2 kinase activity is required for functional type I interferon responses in vivo. PLoS One. 2012;7(6):e39141
• All: 4 reference(s)