Il17a^tm1.1Lky
Targeted Allele Detail

Summary

• Symbol: Il17a^tm1.1Lky
• Name: interleukin 17A; targeted mutation 1.1, Richard M Locksley
• MGI ID: MGI:5439016
• Synonyms: Smart-17A
• Gene: Il17a Location: Chr1:20801129-20804720 bp, + strand Genetic Position: Chr1, 6.45 cM, cytoband A
• Alliance: Il17a^tm1.1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187909
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

Allele Type: Targeted Mutation: Insertion Mutation details: The 3' untranslated region (UTR) was modified to include a floxed neo cassette, an internal ribosomal entry site (IRES) and a non-signaling form of the human nerve growth factor (NGFR) gene. This results in IRES mediated translation of NGFR when the endogenous locus is activated. Cre-mediated recombination removed the neo cassette. (J:187909)

Generation of the Il17a^tm1.1Lky allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il17a Mutation: 25 strains or lines available

References

• Original: J:187909 Price AE, et al., Marking and quantifying IL-17A-producing cells in vivo. PLoS One. 2012;7(6):e39750
• All: 8 reference(s)