Ddx5^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Ddx5^tm1.1Arte
• Name: DEAD box helicase 5; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5463981
• Gene: Ddx5 Location: Chr11:106671181-106680011 bp, - strand Genetic Position: Chr11, 70.01 cM, cytoband E2
• Alliance: Ddx5^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191933
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site followed by FRT-flanked Neo cassette was inserted into intron 1 and an F3-flanked Puro cassette followed by a second loxP site was inserted into intron 12 to produce Ddx5^tm1Arte. The selection cassettes were removed by Flp-mediated recombination, leaving exons 2-11 flanked by lox P sites. (J:191933)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ddx5 Mutation: 39 strains or lines available

References

• Original: J:191933 Nicol SM, et al., The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage. Oncogene. 2013 Jul 18;32(29):3461-9
• All: 6 reference(s)