Nlrp3^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Nlrp3^tm1Bhk
• Name: NLR family, pyrin domain containing 3; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:5465108
• Synonyms: Nlrp3^-
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189777
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The entire coding sequence was replaced with a neo cassette. (J:189777)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 64 strains or lines available

References

• Original: J:189777 Kovarova M, et al., NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol. 2012 Aug 15;189(4):2006-16
• All: 159 reference(s)