Lrrk2tm4.1Mjff
Targeted Allele Detail
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Symbol: |
Lrrk2tm4.1Mjff |
Name: |
leucine-rich repeat kinase 2; targeted mutation 4.1, The Michael J Fox Foundation |
MGI ID: |
MGI:5466851 |
Synonyms: |
Lrrk2D1994A |
Gene: |
Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
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Alliance: |
Lrrk2tm4.1Mjff page
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Germline Transmission: |
Earliest citation of germline transmission:
J:101977
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Parent Cell Line: |
JM8 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: The targeting vector is designed to introduce an aspartate to alanine (D1994A) substitution at codon 1994 in exon 41 of the endogeneous locus. In addition, an FRT-flanked neomycin resistance (neo) cassette was introduced 400 bp downstream of exon 41. Flp-mediated recombination removed the FRT-flanked neo cassette.
(J:101977)
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Original: |
J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017; |
All: |
1 reference(s) |
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