Tg(Hmgcr-SLAMF1)1Hrvt
Transgene Detail

Summary

• Symbol: Tg(Hmgcr-SLAMF1)1Hrvt
• Name: transgene insertion 1, Branka Horvat
• MGI ID: MGI:5476927
• Transgene: Tg(Hmgcr-SLAMF1)1Hrvt Location: unknown
• Alliance: Tg(Hmgcr-SLAMF1)1Hrvt page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hmgcr-SLAMF1)1Hrvt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SLAMF1 (6504)

  Slamf1

  (MGI:1351314)

• Mutation details: A cDNA encoding human signaling lymphocytic activation molecule family member 1 (also called CD150) was inserted into the ubiquitous expression vector pHMG, which contains the promoter, untranslated first exon and first intron of the mouse 3-hydroxy-3-methylglutaryl-Coenzyme A reductase gene and the SV40 polyadenylation signal. Human SLAMF1 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) in multiple tissues of transgenic mice; the highest expression was observed in brain. Flow cytometry using an anti-SLAMF1 monoclonal antibody followed by FITC-conjugated goat anti-mouse antibody demonstrated the presence of human SLAMF1 on the surfaces of cells from various regions of transgenic mouse brains, including cortex, cerebellum/spinal cord, and hippocampus. (J:147406)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:147406 Sellin CI, et al., High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice. J Virol. 2006 Jul;80(13):6420-9
• All: 4 reference(s)