Ceacam1^tm1.1Fta
Targeted Allele Detail

Summary

• Symbol: Ceacam1^tm1.1Fta
• Name: CEA cell adhesion molecule 1; targeted mutation 1.1, Fumihiro Taguchi
• MGI ID: MGI:5496530
• Synonyms: mCEACAM1ba
• Gene: Ceacam1 Location: Chr7:25161132-25177028 bp, - strand Genetic Position: Chr7, 13.84 cM
• Alliance: Ceacam1^tm1.1Fta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198335
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 was replaced with corresponding sequence from Ceacam1^Hv2-r. The allele produces a chimera with the N-terminal domain of Ceacam1^Hv2-r and the C-terminal domain of Ceacam1^Hv2-s. A floxed neomycin resistance cassette was inserted downstream of the modified exon 2. Cre-mediated recombination removed the neomycin resistance cassette. (J:198335)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ceacam1 Mutation: 45 strains or lines available

References

• Original: J:198335 Hirai A, et al., Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b. J Virol. 2010 Jul;84(13):6654-66
• All: 1 reference(s)