Snx31^{tm1a(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Snx31^{tm1a(KOMP)Wtsi}
• Name: sorting nexin 31; targeted mutation 1a, Mouse Biology Program, UC Davis
• MGI ID: MGI:5497029
• Gene: Snx31 Location: Chr15:36504208-36555718 bp, - strand Genetic Position: Chr15, 14.48 cM, cytoband C
• Alliance: Snx31^{tm1a(KOMP)Wtsi} page
• IMPC: Snx31 gene page

Mutation origin

• Mutant Cell Lines: BEPD0008_1_B09, BEPD0008_1_C02, BEPD0008_1_F03, BEPD0008_1_H02, BEPD0008_1_H03
• Germline Transmission: Earliest citation of germline transmission: J:211773
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 36537366 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 36538225. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snx31 Mutation: 25 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 4 reference(s)