Wwox^tm2Ria
Targeted Allele Detail

Summary

• Symbol: Wwox^tm2Ria
• Name: WW domain-containing oxidoreductase; targeted mutation 2, Rami I Aqeila
• MGI ID: MGI:5499851
• Synonyms: Wwox^flox
• Gene: Wwox Location: Chr8:115166395-116079447 bp, + strand Genetic Position: Chr8, 60.99 cM, cytoband E1
• Alliance: Wwox^tm2Ria page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198845
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was floxed. An FRT-flanked neo cassette was inserted downstream of exon 1. Western blot analysis confirmed reduced protein expression in the liver, spleen and testis. (J:198845)

Tumor Data

List all tumor models in MMHCdb carrying Wwox^tm2Ria

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwox Mutation: 59 strains or lines available

References

• Original: J:198845 Abdeen SK, et al., Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype. J Cell Physiol. 2013 Jul;228(7):1377-82
• All: 7 reference(s)