Scara5^tm1Ktry
Targeted Allele Detail

Summary

• Symbol: Scara5^tm1Ktry
• Name: scavenger receptor class A, member 5; targeted mutation 1, Karl Tryggvason
• MGI ID: MGI:5510759
• Gene: Scara5 Location: Chr14:65903852-66002275 bp, + strand Genetic Position: Chr14, 34.35 cM, cytoband D1
• Alliance: Scara5^tm1Ktry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195536
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, which encodes the transmembrane domain, was replaced by the in-frame insertion of the EGFP coding sequence followed by a neomycin selection cassette in reverse orientation. The resulting EGFP fusion protein was unstable. No mRNA was detected in homozygous mice. (J:195536)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Scara5 Mutation: 36 strains or lines available

References

• Original: J:195536 Ojala JR, et al., Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor a5-deficient mice. Am J Pathol. 2013 May;182(5):1681-95
• All: 1 reference(s)