Bcl6^tm1.1Dent
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1.1Dent
• Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Alexander Dent
• MGI ID: MGI:5518542
• Synonyms: Bcl6^fl
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1.1Dent page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202372
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 7, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 9. Exons 7-9 encode the zinc finger domain. The neo selection cassette was subsequently removed from properly targeted mice by crossing to transgenic mice carrying Tg(EIIa-cre)C5379Lmgd. (J:146883, J:202372)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 57 strains or lines available

References

• Original: J:202372 Hollister K, et al., Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model. J Immunol. 2013 Oct 1;191(7):3705-11
• All: 75 reference(s)