Card14tm1Sun
Targeted Allele Detail
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Symbol: |
Card14tm1Sun |
Name: |
caspase recruitment domain family, member 14; targeted mutation 1, John Sundberg |
MGI ID: |
MGI:5550456 |
Gene: |
Card14 Location: Chr11:119198594-119236201 bp, + strand Genetic Position: Chr11, 83.36 cM
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Alliance: |
Card14tm1Sun page
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Germline Transmission: |
Earliest citation of germline transmission:
J:286229
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Parent Cell Line: |
JM8A1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Glycine codon 117 was changed to a serine codon (p.G117S) through a G-to-A point mutation, and an FRT flanked neomycin selection cassette inserted into intron 5. The mutation mimics a psoriasis-associated mutation in human.
(J:286229)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Card14 Mutation: |
39 strains or lines available
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Original: |
J:286229 Sundberg JP, et al., Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity. Exp Mol Pathol. 2019;110:104286 |
All: |
1 reference(s) |
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