Lamb2^npht
Chemically induced Allele Detail

Summary

• Symbol: Lamb2^npht
• Name: laminin, beta 2; nephertiti
• MGI ID: MGI:5578541
• Gene: Lamb2 Location: Chr9:108357080-108367729 bp, + strand Genetic Position: Chr9, 59.4 cM, cytoband F1
• Alliance: Lamb2^npht page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A point mutation that results in the amino acid substitution of tyrosine for cysteine at position 185 (C185Y).
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lamb2 Mutation: 76 strains or lines available

References

• Original: J:208069 Bull KR, et al., Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome. J Pathol. 2014 May;233(1):18-26
• All: 1 reference(s)