Crh^m1H
Chemically induced Allele Detail

Summary

• Symbol: Crh^m1H
• Name: corticotropin releasing hormone; mutation 1, Harwell
• MGI ID: MGI:5578654
• Synonyms: Crh^-120
• Gene: Crh Location: Chr3:19747565-19749560 bp, - strand Genetic Position: Chr3, 5.75 cM
• Alliance: Crh^m1H page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C point mutation at -120 bp with reference to a transcription start (NM_205769) at the consensus sequence of a caudal-type homeobox response element (CDXARE). (J:208708)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Crh Mutation: 42 strains or lines available

References

• Original: J:208708 Bentley L, et al., An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess. Endocrinology. 2014 Mar;155(3):908-22
• All: 4 reference(s)