Pxdn^mhdakta048
Chemically induced Allele Detail

Summary

• Symbol: Pxdn^mhdakta048
• Name: peroxidasin; Martin Hrabe de Angelis kinked tail 048
• MGI ID: MGI:5584201
• Synonyms: KTA048, Pxdn^kta048
• Gene: Pxdn Location: Chr12:29987607-30067657 bp, + strand Genetic Position: Chr12, 13.0 cM
• Alliance: Pxdn^mhdakta048 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A point mutation in exon 19 that results in the amino acid substitution of a termination codon for cysteine at position 1271 (C1272X). This mutation results in a truncation that is predicted to affect the C-terminal region of the peroxidase domain. (J:213336)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pxdn Mutation: 68 strains or lines available

References

• Original: J:213336 Yan X, et al., Peroxidasin is essential for eye development in the mouse. Hum Mol Genet. 2014 Nov 1;23(21):5597-614
• All: 4 reference(s)