Kit^tm1.1Gnf
Targeted Allele Detail

Summary

• Symbol: Kit^tm1.1Gnf
• Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1.1, Genomics Institute of the Novartis Research Foundation
• MGI ID: MGI:5620943
• Synonyms: Kit^T670I
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^tm1.1Gnf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211930
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Not Specified) Mutations: Insertion, Single point mutation Mutation details: A targeting construct introduced a C to T point mutation in exon 14 that results in the amino acid substitution of isoleucine for threonine at position 670 (T607I). Flp-mediated recombination removed an FRT-flanked neomycin resistance cassette with a 3' loxP site introduced downstream of the modified exon 14. (J:211930)

Generation of the Kit^tm1.1Gnf allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:211930 Lau J, et al., Inhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice. PLoS One. 2014;9(1):e84900
• All: 1 reference(s)