Tyk2^tm1Mmul
Targeted Allele Detail

Summary

• Symbol: Tyk2^tm1Mmul
• Name: tyrosine kinase 2; targeted mutation 1, Mathias Muller
• MGI ID: MGI:5636662
• Synonyms: Tyk2^fl, Tyk2^tm1(fl)
• Gene: Tyk2 Location: Chr9:21015364-21042539 bp, - strand Genetic Position: Chr9, 7.71 cM, cytoband A3
• Alliance: Tyk2^tm1Mmul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215350
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exon 3 floxed. (J:215350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyk2 Mutation: 71 strains or lines available

References

• Original: J:215350 Vielnascher RM, et al., Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance. Transgenic Res. 2014 Jun;23(3):519-29
• All: 4 reference(s)