App^tm3.1Tcs
Targeted Allele Detail

Summary

• Symbol: App^tm3.1Tcs
• Name: amyloid beta precursor protein; targeted mutation 3.1, Takaomi C Saido
• MGI ID: MGI:5637817
• Synonyms: App^NL-G-F
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm3.1Tcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212758
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The sequence of exon 16 was humanized by the introduction of the Swedish mutations (p.KM670_671delinsNL) and exon 17 by the introduction of the Arctic (p.E693G) and Beyreuther/Iberian (p.I716F) mutations. A loxP site flanked neomycin resistance gene cassette was inserted in intron 16 and subsequently removed through Cre-mediated recombination. (J:212758)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:212758 Saito T, et al., Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014 May;17(5):661-3
• All: 150 reference(s)