Tg(PF4-RAPGEF1)6A6Cgu
Transgene Detail

Summary

• Symbol: Tg(PF4-RAPGEF1)6A6Cgu
• Name: transgene insertion 6A6, Maria del Carmen Guerrero Arroyo
• MGI ID: MGI:5645686
• Synonyms: C3G-6A6
• Transgene: Tg(PF4-RAPGEF1)6A6Cgu Location: unknown
• Alliance: Tg(PF4-RAPGEF1)6A6Cgu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PF4-RAPGEF1)6A6Cgu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RAPGEF1 (2889)

  Rapgef1

  (MGI:104580)

• Mutation details: The full length human RAPGEF1 gene is expressed under the control of the rat Pf4 promoter to specifically direct transgene expression to megakaryocytes and platelets. (J:188069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:188069 Gutierrez-Herrero S, et al., C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity. Biochim Biophys Acta. 2012 Aug;1823(8):1366-77
• All: 1 reference(s)