Tg(PF4-RAPGEF1*)8A3Cgu
Transgene Detail

Summary

• Symbol: Tg(PF4-RAPGEF1*)8A3Cgu
• Name: transgene insertion 8A3, Maria del Carmen Guerrero Arroyo
• MGI ID: MGI:5645687
• Synonyms: PF4-C3GDeltaCat, tgC3deltaGCat
• Transgene: Tg(PF4-RAPGEF1*)8A3Cgu Location: unknown
• Alliance: Tg(PF4-RAPGEF1*)8A3Cgu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PF4-RAPGEF1*)8A3Cgu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RAPGEF1 (2889)

  Rapgef1

  (MGI:104580)

• Mutation details: The full length human RAPGEF1 gene with a deletion in the sequences encoding the catalytic domain (last 457 bp of the complete cDNA) is expressed under the control of the rat Pf4 promoter to specifically direct transgene expression to megakaryocytes and platelets. (J:188069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:188069 Gutierrez-Herrero S, et al., C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity. Biochim Biophys Acta. 2012 Aug;1823(8):1366-77
• All: 1 reference(s)