Tg(Rip-RASA1*)1Wid
Transgene Detail

Summary

• Symbol: Tg(Rip-RASA1*)1Wid
• Name: transgene insertion 1, Christian Widmann
• MGI ID: MGI:5648069
• Synonyms: mouse 5, RIP-N, Tg(RIP::N)1Wid
• Transgene: Tg(Rip-RASA1*)1Wid Location: unknown
• Alliance: Tg(Rip-RASA1*)1Wid page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rip-RASA1*)1Wid expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RASA1 (5921)

  Rasa1

  (MGI:97860)

  The cDNA carries a human RASA1 fragment N bearing the D157A mutation.

• Mutation details: An HA-tagged form of human RASA1 fragment N bearing the D157A mutation (preventing it from being cleaved by caspases) is expressed under the control of the rat insulin promoter and regulatory sequences of the simian virus 40 (SV40) gene. Four independent RIP-Nexpressing founders were obtained (1, 2, 3 and 4). (J:154378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:154378 Yang JY, et al., Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes. Diabetes. 2009 Nov;58(11):2596-606
• All: 2 reference(s)