Tg(E2F1-luc)1Ech
Transgene Detail
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| Symbol: |
Tg(E2F1-luc)1Ech |
| Name: |
transgene insertion 1, Eric C Holland |
| MGI ID: |
MGI:5648123 |
| Synonyms: |
Tg(E2F1-luc)Ubc |
| Transgene: |
Tg(E2F1-luc)1Ech Location: unknown
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| Alliance: |
Tg(E2F1-luc)1Ech page
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| Transgene Type: |
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Transgenic (Reporter) |
| Mutation: |
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Insertion
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Mutation details: The human E2F1 promoter controls the expression of a firefly luciferase gene. Bioluminescence correlates with the number of tumor cells and with the loss of RB pathway necessary for transformation activity and the proliferative capacity of tumor cells. 8 founders with germline transmission were generated; three of these showed tight cell-cycle regulation of expression in vitro.
(J:93965)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:93965 Uhrbom L, et al., Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nat Med. 2004 Nov;10(11):1257-1260 |
| All: |
2 reference(s) |
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Analysis Tools
