Dyrk1a^tm1Jdc
Targeted Allele Detail

Summary

• Symbol: Dyrk1a^tm1Jdc
• Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; targeted mutation 1, John D Crispino
• MGI ID: MGI:5648391
• Synonyms: Dyrk1a^f
• Gene: Dyrk1a Location: Chr16:94370869-94496376 bp, + strand Genetic Position: Chr16, 55.3 cM
• Alliance: Dyrk1a^tm1Jdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223138
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct contains a loxP site inserted upstream of exon 5 and a FRT-flanked neomycin cassette and a loxP site inserted downstream of exon 6. (J:223138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dyrk1a Mutation: 115 strains or lines available

References

• Original: J:223138 Thompson BJ, et al., DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med. 2015 Jun 1;212(6):953-70
• All: 8 reference(s)