Tg(MMTV-VEGFB*)1Sjh
Transgene Detail

Summary

• Symbol: Tg(MMTV-VEGFB*)1Sjh
• Name: transgene insertion 1, Steven J Harper
• MGI ID: MGI:5660292
• Transgene: Tg(MMTV-VEGFB*)1Sjh Location: unknown
• Alliance: Tg(MMTV-VEGFB*)1Sjh page

Transgene origin

• Strain of Origin: C57BL/6 or CBA/Ca

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-VEGFB*)1Sjh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VEGFB (7423)

  Vegfb

  (MGI:106199)

• Mutation details: The mouse mammary tumor virus enhancer/promoter drives mammary gland-specific expression of the endogenous antiangiogenic splice isoform of human VEGFB (VEGF165b). Line 1 contains three copies of the transgene. (J:135453, J:185243)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

The transgene construct was microinjected into the pronuclei of one-cell embryos from C57BL/6 x CBA/Ca mice.

References

• Original: J:135453 Qiu Y, et al., Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b. FASEB J. 2008 Apr;22(4):1104-12
• All: 3 reference(s)