Del(7Cyp2s1-Cyp2f2)2Ding
Targeted Allele Detail

Summary

• Symbol: Del(7Cyp2s1-Cyp2f2)2Ding
• Name: deletion, Chr 7, Xinxin Ding 2
• MGI ID: MGI:5662456
• Synonyms: Cyp2abfgs-null, Cyp2s1-Cyp2f2^delta
• Gene: Del(7Cyp2s1-Cyp2f2)2Ding Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216691
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Cyp2s1-Cyp2f2)2Ding involves 24 genes/genome features (Gm25947, Gm24865, Cyp2s1 ...) View all
• Mutation details: Cre mediated recombination between Cyp2s1^tm1Ding and Cyp2f2^tm1Ding resulted in a 1.4 Mb deletion. This deletion removes 12 Cyp genes including all Cyp2a, Cyp2b, Cyp2f, Cyp2g and Cyp2s subfamilies. (J:216691)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(7Cyp2s1-Cyp2f2)2Ding Mutation: 1 strain or line available

References

• Original: J:216691 Li L, et al., Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse. Carcinogenesis. 2014 Nov;35(11):2584-91
• All: 1 reference(s)