Col1a1^{tm1(tetO-Vegfc)Mmul}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO-Vegfc)Mmul}
• Name: collagen, type I, alpha 1; targeted mutation 1, Matthias Muller
• MGI ID: MGI:5704365
• Synonyms: Col1a1^{tm1(tetO-VEGFC)Biat}
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO-Vegfc)Mmul} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: KH2 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Col1a1^{tm1(tetO-Vegfc)Mmul} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Vegfc

• Mutation details: A construct containing the tetracycline responsive element, comprising seven tandem copies of the 19-base pair tetracycline operator (tetO), followed by cDNA encoding vascular endothelial growth factor C was introduced by FLP recombinase-mediated cassette exchange (RCME) into the frt docking site of Col1a1^{tm13(neo/hygro*)Jae} in KH2 ES cells. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

Notes

The allele was made in KH2 cells that carry Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} and Col1a1^{tm13(neo/hygro*)Jae} (J:98920). This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)