Mtor^tm1.1Gcon
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1.1Gcon
• Name: mechanistic target of rapamycin kinase; targeted mutation 1.1, Gianluigi Condorelli
• MGI ID: MGI:5707218
• Synonyms: Mtor^fl
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1.1Gcon page

Enlarged hearts with thinned ventricular walls and enlarged cardiac chambers in Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163763
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:163763)

Generation of the Mtor^tm1.1Gcon allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:163763 Zhang D, et al., MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug 2;120(8):2805-16
• All: 3 reference(s)