Dock8^m1
Spontaneous Allele Detail

Summary

• Symbol: Dock8^m1
• Name: dedicator of cytokinesis 8; mutation 1
• MGI ID: MGI:5749378
• Synonyms: Dock8^mu
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^m1 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A C-to-T point mutation located in exon 47 results in a premature stop codon at the arginine codon (p.R2034*). This results in reduced levels of mRNA and absence of detectable levels of protein in bone marrow derived dendritic cells from homozygous mice. This mutation was found in mice carrying Nlrp10^tm1Seis (J:220239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 103 strains or lines available

References

• Original: J:220239 Krishnaswamy JK, et al., Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61
• All: 2 reference(s)