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Tg(Camk2a-rtTA2*M2)4Rsp
Transgene Detail
Summary
Symbol: Tg(Camk2a-rtTA2*M2)4Rsp
Name: transgene insertion 4, Rolf Sprenger
MGI ID: MGI:5749403
Synonyms: rTA-nM2CaMK-4, Tg(CaMKII-rtTA2-nM2
Transgene: Tg(Camk2a-rtTA2*M2)4Rsp  Location: unknown  
Alliance: Tg(Camk2a-rtTA2*M2)4Rsp page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThe transgene expresses a novel tetracycline transactivator (tT) protein variant with a 13-amino acid SV40 nuclear localization signal (nls), optimized codons and, in place of the strong Herpes simplex VP16 activation domain, three ~14-amino acid minimal activation domains under the control of a forebrain-specific promoter fragment, comprising 8.5 kb of 5' flanking sequence and 84 base pairs of the first, noncoding exon, of the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) gene. This is one of four transgenic mouse lines with the SV40 nls that were generated. (J:129344)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:129344 Zhu P, et al., Silencing and un-silencing of tetracycline-controlled genes in neurons. PLoS One. 2007;2(6):e533
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory