Tg(CD68-H2-Ab1^q)#Rhd
Transgene Detail

Summary

• Symbol: Tg(CD68-H2-Ab1^q)#Rhd
• Name: transgene insertion, Rikard Holmdahl
• MGI ID: MGI:5750308
• Synonyms: Macrophage A beta Q, MBQ
• Transgene: Tg(CD68-H2-Ab1^q)#Rhd Location: unknown
• Alliance: Tg(CD68-H2-Ab1^q)#Rhd page

Transgene origin

• Strain of Origin: (B10.P-H2^p/SgTuRhd x C3H.NB-H2^p/SnTuRhd)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD68-H2-Ab1^q)#Rhd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-Ab1 (MGI:103070)

• Mutation details: This transgene contains the human macrophage-specific CD68 promoter through the splice signal flanking the first intron followed by the coding sequence of the mouse MHC class II H2-Ab1^q allele. Expression is strain dependent. (J:175428)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

MBQ is used by the transgene's creators to refer specifically to a strain in which "macrophages exclusively expressed the MHC class II H2-Aq (Aq) on an H2-Ap (Ap) background." (J:175428)

References

• Original: J:175428 Pizzolla A, et al., CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species. Eur J Immunol. 2011 Feb;41(2):403-12
• All: 1 reference(s)