Setdb2^tm1Desr
Targeted Allele Detail

Summary

• Symbol: Setdb2^tm1Desr
• Name: SET domain, bifurcated 2; targeted mutation 1, David E Symer
• MGI ID: MGI:5751798
• Synonyms: Setdb2^GT
• Gene: Setdb2 Location: Chr14:59639458-59678329 bp, - strand Genetic Position: Chr14, 31.48 cM
• Alliance: Setdb2^tm1Desr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222611
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutations: Insertion, Insertion of gene trap vector
• Mutation details: A gene trap (containing an FRT site, loxP site, pGK/EM7 dual promoter, strong splice acceptor from En2, neomycin resistance cassette, polyadenylation sequence, FRT site and loxP) was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Western blot analysis confirmed reduced protein expression in the spleen, lung and bone marrow-derived macrophages. (J:222611)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Setdb2 Mutation: 53 strains or lines available

References

• Original: J:222611 Schliehe C, et al., The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol. 2015 Jan;16(1):67-74
• All: 1 reference(s)