Rock2^tm1.1Skmp
Targeted Allele Detail

Summary

• Symbol: Rock2^tm1.1Skmp
• Name: Rho-associated coiled-coil containing protein kinase 2; targeted mutation 1.1, Sandra Kumper
• MGI ID: MGI:5752066
• Synonyms: Rock2^f
• Gene: Rock2 Location: Chr12:16944896-17037824 bp, + strand Genetic Position: Chr12, 8.04 cM, cytoband A3
• Alliance: Rock2^tm1.1Skmp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229442
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exon 6 floxed. (J:229442)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rock2 Mutation: 60 strains or lines available

References

• Original: J:229442 Kumper S, et al., Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. Elife. 2016;5:e12203
• All: 1 reference(s)