Ace2em#Yngh
Endonuclease-mediated Allele Detail
|
Symbol: |
Ace2em#Yngh |
Name: |
angiotensin converting enzyme 2; endonuclease-mediated mutation, Huanming Yang |
MGI ID: |
MGI:5752578 |
Synonyms: |
ACE2-KO |
Gene: |
Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
|
Alliance: |
Ace2em#Yngh page
|
|
|
Allele Type: |
|
Endonuclease-mediated (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: TALEN technology was used to introduce mutations into exon 2. The population analyzed for phenotype contained individuals with alleles from 3 lines (#17, #20 and #24) containing: (1) a 4 bp deletion; (2) a 10 bp deletion; (3) a 3 bp deletion; (4) a 20 bp deletion with a single bp insertion; and (5) a single bp insertion. Northern blot analysis confirmed reduced expression of a long isoform. The short isoform is not detected in the colon of knock-out or control mice. The pound symbol (#) is used when no line is specified or lines are pooled.
(J:221616)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Ace2 Mutation: |
63 strains or lines available
|
|
Original: |
J:221616 Liu C, et al., Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation. Transgenic Res. 2015 Jun;24(3):433-46 |
All: |
2 reference(s) |
|